Yes it is true, there is some problem with APC cache PHP module and WordPress SuperCache plugin.
I have experienced those random blank screens with an error 500, just like it is described here:
My current configuration is:
Ubuntu 12.04 32 bits
WordPress SuperCache 1.3.1
The issue has been identified by the plugin dev team: https://wordpress.org/plugins/wp-super-cache/faq/
The “white screen of death” or a blank page when you visit your site is almost always caused by a PHP error but it may also be caused by APC. Disable that PHP extension if you have trouble and replace with eAccelerator or Xcache.
In order to disable the APC module:
sudo nano /etc/php5/apache2/conf.d/apc.ini
and comment the line
Then restart apache
sudo service apache2 restart